Presynaptic Ca(2+) influx at a mouse central synapse with Ca(2+) channel subunit mutations.

@article{Qian2000PresynapticCI,
  title={Presynaptic Ca(2+) influx at a mouse central synapse with Ca(2+) channel subunit mutations.},
  author={Jing Qian and Jeffrey L Noebels},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2000},
  volume={20 1},
  pages={163-70}
}
Genetic alterations in Ca(2+) channel subunits can be used to study the interaction among channel subunits and their roles in channel function. P/Q- and N-type Ca(2+) channels reside at the presynaptic terminal and control the release of neurotransmitter at mammalian central synapses. We used fluorescence imaging techniques to investigate presynaptic Ca(2+) currents and neurotransmitter release at hippocampal Schaffer collateral synapses in both tottering (tg, alpha(1A) subunit) and lethargic… CONTINUE READING

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