Presynaptic BDNF Required for a Presynaptic but Not Postsynaptic Component of LTP at Hippocampal CA1-CA3 Synapses

@article{Zakharenko2003PresynapticBR,
  title={Presynaptic BDNF Required for a Presynaptic but Not Postsynaptic Component of LTP at Hippocampal CA1-CA3 Synapses},
  author={Stanislav S Zakharenko and S. Patterson and I. Dragatsis and S. Zeitlin and S. Siegelbaum and E. Kandel and A. Morozov},
  journal={Neuron},
  year={2003},
  volume={39},
  pages={975-990}
}
  • Stanislav S Zakharenko, S. Patterson, +4 authors A. Morozov
  • Published 2003
  • Medicine, Biology
  • Neuron
  • Brain-derived neurotrophic factor (BDNF) has been implicated in several forms of long-term potentiation (LTP) at different hippocampal synapses. Using two-photon imaging of FM 1-43, a fluorescent marker of synaptic vesicle cycling, we find that BDNF is selectively required for those forms of LTP at Schaffer collateral synapses that recruit a presynaptic component of expression. BDNF-dependent forms of LTP also require activation of L-type voltage-gated calcium channels. One form of LTP with… CONTINUE READING
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