Presynaptic 5-HT auto- and heteroreceptors in the human central and peripheral nervous system.

@article{Gthert1996Presynaptic5A,
  title={Presynaptic 5-HT auto- and heteroreceptors in the human central and peripheral nervous system.},
  author={Manfred G{\"o}thert and Klaus Fink and Daniel R Froelich and James Anthony Likungu and Gerhard J Molderings and Eberhard Schlicker and J. Zentner},
  journal={Behavioural brain research},
  year={1996},
  volume={73 1-2},
  pages={89-92}
}
In view of the potential pathophysiological and therapeutic implications, presynaptic 5-HT auto- and heteroreceptors have been identified and characterized in isolated human tissues and their functional role has been determined. Such investigations have been carried out in different laboratories including that of the authors. Basic evidence for the involvement of inhibitory 5-HT receptors in modulation of 5-HT release in the cerebral cortex was obtained in slices: exogenous 5-HT inhibited 5-HT… CONTINUE READING