Presymptomatic spinal cord neurometabolic findings in SOD1-positive people at risk for familial ALS.

@article{Carew2011PresymptomaticSC,
  title={Presymptomatic spinal cord neurometabolic findings in SOD1-positive people at risk for familial ALS.},
  author={John D Carew and Govind Nair and Peter Munch Andersen and Joanne Wuu and Susan Gronka and X Hu and Michael Benatar},
  journal={Neurology},
  year={2011},
  volume={77 14},
  pages={1370-5}
}
OBJECTIVE It has been speculated that amyotrophic lateral sclerosis (ALS) is characterized by a premanifest period during which neurodegeneration precedes the appearance of clinical manifestations. Magnetic resonance spectroscopy (MRS) was used to measure ratios of neurometabolites in the cervical spine of asymptomatic individuals with a mutation in the SOD1 gene (SOD1+) and compare their neurometabolic ratios to patients with ALS and healthy controls. METHODS A cross-sectional study of (1)H… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
23 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 23 extracted citations

Similar Papers

Loading similar papers…