Presymptomatic motor neuron loss and reactive astrocytosis in the SOD1 mouse model of amyotrophic lateral sclerosis.

@article{Feeney2001PresymptomaticMN,
  title={Presymptomatic motor neuron loss and reactive astrocytosis in the SOD1 mouse model of amyotrophic lateral sclerosis.},
  author={Sandra J Feeney and Penelope A. McKelvie and Lawrence Austin and M J Bernadette Jean-Francois and Robert Kapsa and Steve Tombs and Edward Byrne},
  journal={Muscle & nerve},
  year={2001},
  volume={24 11},
  pages={1510-9}
}
In familial amyotrophic lateral sclerosis (fALS), there is a need to establish more precisely the progression of the disease, particularly whether there is gradual presymptomatic neuronal loss or an abrupt loss coinciding with the symptomatic stage. To elucidate this, we investigated the progression of motor neuron loss through morphological techniques, reactive astrocytosis, and expression of ubiquitin and neurofilament proteins, by immunohistochemistry, in SOD1 G93A mice with a protracted… CONTINUE READING
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