Presurgical chemotherapy compared with immediate surgery and adjuvant chemotherapy for nonmetastatic osteosarcoma: Pediatric Oncology Group Study POG-8651.

@article{Goorin2003PresurgicalCC,
  title={Presurgical chemotherapy compared with immediate surgery and adjuvant chemotherapy for nonmetastatic osteosarcoma: Pediatric Oncology Group Study POG-8651.},
  author={Allen M Goorin and Douglas J. Schwartzentruber and Meenakshi Devidas and Mark C. Gebhardt and Alberto G. Ayala and Michael Brennan Harris and Lee J. Helman and Holcombe E. Grier and Michael P. Link},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2003},
  volume={21 8},
  pages={1574-80}
}
PURPOSE Successful therapeutic interventions to prevent disease progression in patients with nonmetastatic osteosarcoma have included surgery with adjuvant chemotherapy. Presurgical chemotherapy has been advocated for these patients because of putative improvement in event-free survival (EFS). The advantages of presurgical chemotherapy include early administration of systemic chemotherapy, shrinkage of primary tumor, and pathologic identification of risk groups. The theoretic disadvantage is… CONTINUE READING
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