Presumed Glioblastoma Multiforme: A Case for Biopsy Prior to Treatment.
@article{Staller2016PresumedGM,
title={Presumed Glioblastoma Multiforme: A Case for Biopsy Prior to Treatment.},
author={Aileen Staller},
journal={Clinical journal of oncology nursing},
year={2016},
volume={20 1},
pages={
95-7
}
}Glioblastoma multiforme (GBM) is the most lethal and aggressive primary brain tumor. Several other abnormalities (neoplastic, infectious, or vascular) can mimic symptoms seen with GBM. This article reviews GBM and presents a case study that demonstrates the rationale for biopsy and pathologic diagnosis prior to the initiation of treatment for malignant brain tumors.
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References
SHOWING 1-10 OF 21 REFERENCES
Early necrosis following concurrent Temodar and radiotherapy in patients with glioblastoma
- MedicineJournal of Neuro-Oncology
- 2006
In 51 consecutive patients treated according to this regimen, 7 patients manifested surgically confirmed early necrosis without evidence of recurrent tumor, suggesting that daily TMZ may represent a potent radiosensitizing regimen.
Temozolomide in malignant gliomas: current use and future targets
- MedicineCancer Chemotherapy and Pharmacology
- 2009
Developing concerns regarding the use of TMZ, imaging of malignant gliomas, and the pharmacology of TMZ—mechanism of action, scheduling and strategies for overcoming resistance are summarized.
Dose-intensity temozolomide after concurrent chemoradiotherapy in operated high-grade gliomas
- MedicineJournal of Neuro-Oncology
- 2008
The toxicity of the TMZ dose-dense regimen was very low, and results seem to be encouraging for RPA lower classes (patients with good prognostic factors).
Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas.
- MedicineJournal of neuropathology and experimental neurology
- 2005
Data is summarized on incidence rates, survival, and genetic alterations from population-based studies of astrocytic and oligodendrogliomas that were carried out in the Canton of Zurich, Switzerland to suggest that the acquisition of TP53 mutations in these glioblastoma subtypes may occur through different mechanisms.
Temozolomide: a milestone in neuro-oncology and beyond?
- Medicine, BiologyExpert review of anticancer therapy
- 2006
The benefit of temozolomide chemotherapy is restricted to patients whose tumors have a methylated methylguanine methyltransferase gene promotor and are thus unable to repair some of the chemotherapy-induced DNA damage.
Robbins & Cotran Pathologic Basis of Disease
- Medicine
- 2014
The pathologic basis of disease is determined by X-ray diffraction analysis of the granuloma with an Higgs–Cotran–Bouchut–Seiden ratio of 3:1.
Dose‐dense temozolomide regimens
- Medicine, BiologyCancer
- 2010
Preclinical and clinical evidence suggests that temozolomide‐associated lymphodepletion may enhance the host immune response to tumor‐associated antigens and/or immunotherapy and may overcome tumor‐mediated immunosuppression.
Robbins and Cotran pathologic basis of disease
- Medicine
- 2015
Robbins and Cotan pathologic basis of disease / , Robbins and Cotran pathologicBased on X-ray diffraction analysis, autopsies showed clear trends in prognosis of central giant cell granuloma.