Prestin up-regulation in chronic salicylate (aspirin) administration: An implication of functional dependence of prestin expression

@article{Yu2008PrestinUI,
  title={Prestin up-regulation in chronic salicylate (aspirin) administration: An implication of functional dependence of prestin expression},
  author={Niefang Yu and M.-L. Zhu and Briana Johnson and Gary Moyle and Richard Oliver Jones and H.-B. Hu J.-Y. Zhao},
  journal={Cellular and Molecular Life Sciences},
  year={2008},
  volume={65},
  pages={2407-2418}
}
Abstract.Salicylate (aspirin) can reversibly eliminate outer hair cell (OHC) electromotility to induce hearing loss. Prestin is the OHC electromotility motor protein. Here we report that, consistence with increase in distortion product otoacoustic emission, long-term administration of salicylate can increase prestin expression and OHC electromotility. The prestin expression at the mRNA and protein levels was increased by three- to four-fold. In contrast to the acute inhibition, the OHC… CONTINUE READING
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