Prestin surface expression and activity are augmented by interaction with MAP1S, a microtubule-associated protein.

@article{Bai2010PrestinSE,
  title={Prestin surface expression and activity are augmented by interaction with MAP1S, a microtubule-associated protein.},
  author={Jun-Ping Bai and Alexei A. Surguchev and Yudelca Ogando and Lei Song and Shumin Bian and Joseph Santos-Sacchi and Dhasakumar S. Navaratnam},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 27},
  pages={20834-43}
}
Prestin is a member of the SLC26 family of anion transporters that is responsible for outer hair cell (OHC) electromotility. Measures of voltage-evoked charge density (Q(sp)) of prestin indicated that the protein is highly expressed in OHCs, with single cells expressing up to 10 million molecules within the lateral membrane. In contrast, charge density measures in transfected cells indicated that they express, at best, only a fifth as many proteins on their surface. We sought to determine… CONTINUE READING