Pressure-volume curves of systemic and pulmonary circuit.

@article{Harlan1967PressurevolumeCO,
  title={Pressure-volume curves of systemic and pulmonary circuit.},
  author={J. C. Harlan and E E Smith and T Q Richardson},
  journal={The American journal of physiology},
  year={1967},
  volume={213 6},
  pages={
          1499-503
        }
}
HARLAN, JAMES C., ELVIN E. SMITH, AND T. Q. RICHARDSON. Pressure-volume curves of the systemic and pulmonary circuit. Am. J. Phvsiol. 213(6): 1499-1503. 1967.-Mean svstemic pressure (klSP) and mean pulmonary pressure (MPP) were measured in eight mongrel dogs immediately after acute changes in blood volume. A decrease in blood volume of only 12 % decreased MPP to 0 mm Hg and decreased MSP to only 2 mm Hg. From the control value of 6.4 mm Hg for MSP, an addition of 6.4 mm Hg was observed for each… 
View on PubMed
ajplegacy.physiology.org
27 Citations
Background Citations
3
Results Citations
1

Figures from this paper

27 Citations

Citation Type

Citation Type

Reflex Venoconstriction and Capacity Vessel Pressure‐Volume Relationships in Dogs
TLDR
Reflexogenic control of vascular capacity was studied by measuring the mean circulatory pressure (PMC) at various blood volumes and found that less than half of the compensation for hemorrhage during the first 5 minutes came from the reflex venoconstriction.
A two-compartment model of systemic circulation: Influence of transmural pressure
TLDR
A computer simulation of the effects of cardiac output variations induced by volume loading substantiates the conclusions that the observed curvature of pressure—flow relationships is due to increasing splanchnic venous resistance with upstream splan Schnic pressure while the observed linearity of volume— flow relationships isdue to the offsetting effects of increasing venous resistances and decreasing compliances with increasing upstream venous pressure.
Effect of Thoracic Blood Volume Changes on Steady State Cardiac Output
TLDR
The results indicate that the heart-lung compartment contains a significant volume which is under cardiac control and which the heart can modulate the steady state cardiac output by adjusting the mean systemic pressure.
Increased effective vascular compliance and venous pooling of intravascular volume during sustained venodilation in conscious dogs
TLDR
It is concluded that molsidomine exerts its hypotensive effect by dilation within the vascular low-pressure system and that this dilation can be described quantitatitely in conscious animals by the analysis of the total effective vascular compliance.
Mean systemic filling pressure as a characteristic pressure for venous return
TLDR
Guyton's theory on venous return, implying a linear relationship between blood flow and central venous pressure, was tested in an intact circulation after thoracotomy and airtight chest closure and the point where mean systemic filling pressure exists during normal flow conditions was predicted at a characteristic location in the peripheral venous system.
Total Systemic Vascular Compliance Measured as Incremental Volume‐Pressure Ratio
TLDR
A method to measure the compliance, defined as ΔVΔP, of the total systemic vascular bed (Ct) without stopping systemic flow is developed and indicated no significant difference between measurements of bleeding and reinfusion, measurements with different initial venous pressures or blood volume, or measurements before and after vagotomy.
Effective Compliance of the Total Vascular Bed and the Intrathoracic Compartment Derived from Changes in Central Venous Pressure Induced by Volume Changes in Man
TLDR
In eight male subjects the blood volume was changed by hemorrhage and transfusion and the capacity of the circulatory system was restricted by infusion of norepinephrine, lower body positive pressure, or both and the effective compliance was 2.3 ml/mm Hg kg−1 body weight.
Effects of Nitroprusside on Venous Return and Central Blood Volume in the Absence and Presence of Acute Heart Failure
TLDR
It is concluded that the differing effects of nitroprusside in acute cardiac failure are due primarily to an increased shift of blood from the central circulation in the failure state compared with the normal circulation.
Reflex Vascular Capacity Reduction in the Dog
  • C. Rothe
  • Medicine
    Circulation research
  • 1976
TLDR
The maximum degree and time course of active reflex venoconstriction in chloralose-anesthetized dogs was studied and the maximal degree of active venoconStriction induced by circulatory arrest was 9.0 ml/kg during the 1st minute of cardiac fibrillation.
Effects of positive end-expiratory pressure on the gradient for venous return.
TLDR
It is concluded that PEEP increases Pms by both reflex and mechanical means independent of increased abdominal pressure, as well as the equilibrium PRA during ventricular fibrillation.
...
...

References

SHOWING 1-9 OF 9 REFERENCES
Effect of mean circulatory filling pressure and other peripheral circulatory factors on cardiac output.
TLDR
A mathematical circuit analysis of the closed circuit circulatory system has been made and two factors which have proved to be of importance are ‘capacitance’ and ‘mean circulatory filling pressure’.
ROLE OF SYMPATHETIC NERVOUS SYSTEM IN SURVIVING ACUTE HEMORRHAGE.
  • S. Chien
  • Medicine
    The American journal of physiology
  • 1964
TLDR
Twenty unanesthetized, chronically sympathectomized-splenectomized dogs were subjected to rapid hemorrhages varying from 29 to 49% of the control blood volume and the blood volume remaining after hemorrhage was correlated with the fate of the dog.
Pressure-volume curves of the arterial and venous systems in live dogs.
Pressure-volume curves have been recorded for the arterial and the venous systems of live dogs. The quantity of blood in the arterial system of a 12-kg dog was found to average approximately 60 cc ...
A physiologic reference point for measuring circulatory pressures in the dog; particularly venous pressure.
A physiologic reference point for measuring pressures in the circulatory system has been located by rotating dogs into all positions in space and locating the axes of rotation at which least variat...
Relationship of the mean circulatory filling pressure to cardiac output
CIRCULATORY PHYSIOLOGY: Cardiac Output and Its Regulation
Myocardial contractility as described by ventricular function curves; observations on Starling's law of the heart.
Control Theory and Riologzcal xystems
  • p. 159-l
  • 1963
Studies on the relationship of mean circulatory filling pressure , right atria 1 pressure , and venous return in dead dogs
  • Am . J . Physiol .
  • 1952