Pressure regulates osteoclast formation and MCSF expression in marrow culture.

@article{Rubin1997PressureRO,
  title={Pressure regulates osteoclast formation and MCSF expression in marrow culture.},
  author={Janet Rubin and Diane M Biskobing and Xiujun Fan and Clinton T. Rubin and Kate McLeod and William R Taylor},
  journal={Journal of cellular physiology},
  year={1997},
  volume={170 1},
  pages={81-7}
}
One of the forces generated during skeletal loading is hydrostatic pressure. In the work presented here, the ability of increased pressure to influence recruitment of osteoclasts was evaluated. Murine marrow cultures, with pO2 and pCO2 kept constant, were subjected to either control (1.0 atm) or elevated (1.37 or 2.0 atm) hydrostatic pressure. As compared to control, cultures pressurized for 6 days at 1.37 atm formed less osteoclast-like cells (OCLC) (71 +/- 6% of control, P < 0.0001). A… CONTINUE READING

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