Pressure overload differentially affects respiratory capacity in interfibrillar and subsarcolemmal mitochondria.

@article{Schwarzer2013PressureOD,
  title={Pressure overload differentially affects respiratory capacity in interfibrillar and subsarcolemmal mitochondria.},
  author={Michael Schwarzer and Andrea Schrepper and Paulo A. Amorim and Moritz Osterholt and Torsten Doenst},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2013},
  volume={304 4},
  pages={
          H529-37
        }
}
Years ago a debate arose as to whether two functionally different mitochondrial subpopulations, subsarcolemmal mitochondria (SSM) and interfibrillar mitochondria (IFM), exist in heart muscle. Nowadays potential differences are often ignored. Presumably, SSM are providing ATP for basic cell function, whereas IFM provide energy for the contractile apparatus. We speculated that two distinguishable subpopulations exist that are differentially affected by pressure overload. Male Sprague-Dawley rats… 
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