Pressure monitoring of continuous-flow solid-phase peptide synthesis.


We describe the noninvasive real-time pressure monitoring of Boc- and Fmoc-based peptide synthesis. Pressure was measured using a resistance strain gauge attached to the inlet of a continuous-flow reactor of variable volume. In the assembly of the 'difficult' polyalanine sequence, it was shown that pressure monitoring can reveal structural variations of the… (More)


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@article{Baru2001PressureMO, title={Pressure monitoring of continuous-flow solid-phase peptide synthesis.}, author={Michael B Baru and Leyla G Mustaeva and I V Vagenina and Elena Yu Gorbunova and V V Cherskiĭ}, journal={The journal of peptide research : official journal of the American Peptide Society}, year={2001}, volume={57 3}, pages={193-202} }