Pressure-induced protein-folding/unfolding kinetics.

  title={Pressure-induced protein-folding/unfolding kinetics.},
  author={Nathan J Hillson and Jos{\'e} N. Onuchic and Angel E. Garc{\'i}a},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={96 26},
We use an off-lattice minimalist model to describe the effects of pressure in slowing down the folding/unfolding kinetics of proteins when subjected to increasingly larger pressures. The potential energy function used to describe the interactions between beads in the model includes the effects of pressure on the pairwise interaction of hydrophobic groups in water. We show that pressure affects the participation of contacts in the transition state. More significantly, pressure exponentially… CONTINUE READING


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