Pressure-induced oxidative activation of PKG enables vasoregulation by Ca2+ sparks and BK channels

  title={Pressure-induced oxidative activation of PKG enables vasoregulation by Ca2+ sparks and BK channels},
  author={Kaivan Khavandi and Rachael L. Baylie and Sarah A. Sugden and Majid Ahmed and Vikt{\'o}ria Csat{\'o} and Philip Eaton and David C. Hill-Eubanks and Adrian D. Bonev and Mark T. Nelson and Adam Seth Greenstein},
  journal={Science Signaling},
Activation of Ca2+-sensitive, large-conductance potassium (BK) channels in vascular smooth muscle cells (VSMCs) by local, ryanodine receptor–mediated Ca2+ signals (Ca2+ sparks) acts as a brake on pressure-induced (myogenic) vasoconstriction—a fundamental mechanism that regulates blood flow in small resistance arteries. We report that physiological intraluminal pressure within resistance arteries activated cGMP-dependent protein kinase (PKG) in VSMCs through oxidant-induced formation of an… CONTINUE READING
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