Pressure-induced connective tissue synthesis in pulmonary artery segments is dependent on intact endothelium.

@article{Tozzi1989PressureinducedCT,
  title={Pressure-induced connective tissue synthesis in pulmonary artery segments is dependent on intact endothelium.},
  author={Carol A. Tozzi and George J Poiani and Andrea M Harangozo and Charles D. Boyd and David R J Riley},
  journal={The Journal of clinical investigation},
  year={1989},
  volume={84 3},
  pages={1005-12}
}
Physiologic stimuli of connective tissue accumulation in pulmonary vascular remodeling are poorly defined. We postulated that increased pressure within central pulmonary arteries is a stimulus for connective tissue synthesis and the response is dependent on an intact endothelium. Mechanical tension equivalent to 50 mmHg pressure was applied for 4 h to isolated rat main pulmonary arteries (endothelium intact or removed), and incorporation of [14C]proline into collagen, [14C]valine into elastin… CONTINUE READING