Pressure-independent effects of pharmacological stimulation of soluble guanylate cyclase on fibrosis in pressure-overloaded rat heart

@article{Masuyama2009PressureindependentEO,
  title={Pressure-independent effects of pharmacological stimulation of soluble guanylate cyclase on fibrosis in pressure-overloaded rat heart},
  author={Hiroyuki Masuyama and Toshihiro Tsuruda and Yoko Sekita and Kinta Hatakeyama and Tomohiko Imamura and Junzo Kato and Yoshihito Asada and J. -P. Stasch and Kazuo Kitamura},
  journal={Hypertension Research},
  year={2009},
  volume={32},
  pages={597-603}
}
Cardiac fibrosis is a hallmark of cardiovascular remodeling associated with hypertension. The purpose of this study was to explore the effect and mechanism of soluble guanylate cyclase (sGC) stimulator BAY 41–2272, leading to intracellular cyclic guanosine monophosphate (cGMP) elevation, on the remodeling process induced by pressure overload. Seven-week-old male Wistar rats with hypertension induced by suprarenal aortic constriction (AC) were treated orally with 2 mg kg−1 day−1 of BAY 41–2272… CONTINUE READING
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