Pressure gradient, not exposure duration, determines the extent of epithelial cell damage in a model of pulmonary airway reopening.

@article{Kay2004PressureGN,
  title={Pressure gradient, not exposure duration, determines the extent of epithelial cell damage in a model of pulmonary airway reopening.},
  author={Sarina S Kay and Anastacia M Bilek and Kay C. Dee and D. P. Gaver},
  journal={Journal of applied physiology},
  year={2004},
  volume={97 1},
  pages={269-76}
}
The reduction of tidal volume during mechanical ventilation has been shown to reduce mortality of patients with acute respiratory distress syndrome, but epithelial cell injury can still result from mechanical stresses imposed by the opening of occluded airways. To study these stresses, a fluid-filled parallel-plate flow chamber lined with epithelial cells was used as an idealized model of an occluded airway. Airway reopening was modeled by the progression of a semi-infinite bubble of air… CONTINUE READING
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