• Corpus ID: 245704435

Pressure -- area loop based phenotypic classification and mechanics of esophagogastric junction physiology

  title={Pressure -- area loop based phenotypic classification and mechanics of esophagogastric junction physiology},
  author={Guy Elisha and Sourav Halder and Shashank Acharya and Dustin A. Carlson and Wenjun Kou and Peter J. Kahrilas and John E. Pandolfino and Neelesh A. Patankar},
The esophagogastric junction (EGJ) is located at the distal end of the esophagus and acts as a valve allowing swallowed materials to enter the stomach and preventing acid reflux. Irregular weakening or stiffening of the EGJ muscles result in changes to its opening and closing patterns which can progress into esophageal disorders. Therefore, understanding the physics behind the opening and closing cycle of the EGJ provides a mechanistic insight into its function and can help identify the… 

A mechanics--based perspective on the function of human sphincters during functional luminal imaging probe manometry

This work provides a fundamental mechanical understanding of human sphincters and can be used to identify normal and abnormal phenotypes for the different spharkers and help in creating physiomarkers based on work calculation.



Mechanical properties of the esophagus in eosinophilic esophagitis.

Esophageal distensibility, defined by the change in the narrowest measurable CSA within the distal esophagus vs intraluminal pressure was significantly reduced in EoE patients compared with controls.

Regulation and dysregulation of esophageal peristalsis by the integrated function of circular and longitudinal muscle layers in health and disease.

  • R. Mittal
  • Medicine
    American journal of physiology. Gastrointestinal and liver physiology
  • 2016
The regulation and dysregulation of peristalsis by the coordinated and discoordinated function of circular and longitudinal muscle layers in health and diseased states is summarized and the possibility that the discoordination between two muscle layers plays a role in the genesis of esophageal symptoms is suggested.

Upper esophageal sphincter mechanical states analysis: a novel methodology to describe UES relaxation and opening

The swallowing muscles that influence upper esophageal sphincter (UES) opening are centrally controlled and modulated by sensory information. Activation of neural inputs to these muscles, the

Loop Analysis of the Anal Sphincter Complex in Fecal Incontinent Patients using Functional Luminal Imaging Probe.

AP and AT-loops are proposed as novel ways to assess anal sphincter and PRM function by real-time measurement of pressure and area within the anal canal through functional luminal imaging probe recordings.

Peristaltic regimes in esophageal transport

A FLIP device gives cross-sectional area along the length of the esophagus and one pressure measurement, both as a function of time. Deducing mechanical properties of the esophagus including wall

Functional luminal imaging probe topography: an improved method for characterizing esophageal distensibility in eosinophilic esophagitis

New techniques can be leveraged to improve data analysis and presentation using EndoFLIP assessment of the esophageal body in EoE and may be helpful in defining clinically relevant phenotypes and guiding treatment strategies.

Current clinical approach to achalasia.

It appears that laparoscopic Heller myotomy with partial fundoplication is superior to endoscopic methods in achieving long-term relief of symptoms in the majority of patients, but the current clinical approach to achalasia will depend not only on patients' characteristics and clinical subtypes of the disease, but also on local expertise and patient preferences.

Classifying Esophageal Motility by FLIP Panometry: A Study of 722 Subjects With Manometry

FLIP panometry serves as a well-tolerated method that can complement, or in some cases be an alternative to HRM, for evaluating esophageal motility disorders and parallels the swallow-associated motility evaluation provided with HRM and CCv4.0.

The Functional Lumen Imaging Probe Detects Esophageal Contractility Not Observed With Manometry in Patients With Achalasia.

The presence and patterns of contractility detected with FLIP topography may represent variations in pathophysiology, such as mechanisms of panesophageal pressurization in patients with type II achalasia.