Pressure and shear differentially alter human articular chondrocyte metabolism: a review.

@article{Smith2004PressureAS,
  title={Pressure and shear differentially alter human articular chondrocyte metabolism: a review.},
  author={Robert L. Smith and Dennis R. Carter and David J. Schurman},
  journal={Clinical orthopaedics and related research},
  year={2004},
  volume={427 Suppl},
  pages={S89-95}
}
Homeostasis of articular cartilage depends in part on mechanical loads generated during daily activity whereas inappropriate joint loads result in focal degeneration of cartilage, as occurs in osteoarthritis. We will review results of a series of questions regarding the effects of two types of mechanical loads-intermittent hydrostatic pressure and shear stress-on adult human articular chondrocytes in high-density monolayer culture. Intermittent hydrostatic pressure increased aggrecan and Type… CONTINUE READING
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