Pressure activates colon cancer cell adhesion by inside-out focal adhesion complex and actin cytoskeletal signaling.

@article{Thamilselvan2004PressureAC,
  title={Pressure activates colon cancer cell adhesion by inside-out focal adhesion complex and actin cytoskeletal signaling.},
  author={Vijayalakshmi Thamilselvan and Marc D. Basson},
  journal={Gastroenterology},
  year={2004},
  volume={126 1},
  pages={8-18}
}
BACKGROUND AND AIMS Few circulating tumor cells implant or cause metastasis. We hypothesized that venous or lymphatic pressure or iatrogenic pressure during resection activates signals governing malignant colonocyte adhesion. METHODS We studied the effect of 15 mm Hg increased pressure for 30 minutes on adhesion of primary human colon cancer cells and SW620 colonocytes to collagen and endothelial cells. We modulated integrin affinity with extracellular cations. We assessed binding affinity by… CONTINUE READING
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