Pressor Response to l-Sar-8-Ala-Angiotensin II ( Saralasin ) in Hypertensive Subjects

Abstract

An angiotensin II (A II) analogue (l-Sar-8-Alaangiotensin II) (saralasin) was infused into 418 untreated hypertensive subjects during a 1-day evaluation while blood pressure was recorded every 2 minutes by Arteriosonde. At 5 ftg/kg per min, saralasin produced a change in mean blood pressure which correlated significantly (r = 0 . 5 4 , P < 0.001) with the… (More)

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