Preserving the Replication Fork in Response to Nucleotide Starvation: Evading the Replication Fork Collapse Point

Abstract

Replication fork progression is blocked by a variety impediments including DNA damage, aberrant DNA structures, or nucleotide depletion [1-3]. The response to replication fork stalling varies according the type of replication inhibition, the number of stalled forks and the duration of the treatment [3-7]. Stalled replication forks are at increased risk for… (More)

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3 Figures and Tables