Preserving renal function in patients with membranous nephropathy: daily oral chlorambucil compared with intermittent monthly pulses of cyclophosphamide.

@article{Reichert1994PreservingRF,
  title={Preserving renal function in patients with membranous nephropathy: daily oral chlorambucil compared with intermittent monthly pulses of cyclophosphamide.},
  author={Louis J M Reichert and Frans Th M Huysmans and K. A{\ss}mann and RobertA. P. Koene and Jack F. M. Wetzels},
  journal={Annals of internal medicine},
  year={1994},
  volume={121 5},
  pages={
          328-33
        }
}
In most patients with membranous nephropathy, the disease follows a benign course; only one fourth of the patients develop renal insufficiency [1-4]. Results of randomized clinical trials assessing the efficacy of corticosteroids [5-7] and chlorambucil [8, 9] in patients with membranous nephropathy and normal renal function are controversial. Because in most untreated patients renal function remains normal and spontaneous remissions of proteinuria develop, it does not seem justified to use… CONTINUE READING
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Pathogenesis and treatment of membranous nephropathy

  • JS Cameron
  • Kidney Int. ;15:88-103
  • 1994
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