Preserved glucose tolerance in high-fat-fed C57BL/6 mice transplanted with PPARγ−/−, PPARδ−/−, PPARγδ−/−, or LXRαβ−/− bone marrow*

@article{Marathe2009PreservedGT,
  title={Preserved glucose tolerance in high-fat-fed C57BL/6 mice transplanted with PPARγ−/−, PPARδ−/−, PPARγδ−/−, or LXRαβ−/− bone marrow*},
  author={Chaitra Marathe and Michelle N. Bradley and Cynthia Hong and Lily C Chao and Damien C Wilpitz and Jon V. Salazar and Peter Tontonoz},
  journal={Journal of Lipid Research},
  year={2009},
  volume={50},
  pages={214 - 224}
}
Macrophage lipid metabolism and inflammatory responses are both regulated by the nuclear receptors PPAR and LXR. Emerging links between inflammation and metabolic disease progression suggest that PPAR and LXR signaling may alter macrophage function and thereby impact systemic metabolism. In this study, the function of macrophage PPAR and LXR in Th1-biased C57BL/6 mice was tested using a bone marrow transplantation approach with PPARgamma(-/-), PPARdelta(-/-), PPARgammadelta(-/-), and… CONTINUE READING
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