Preserved GLP-1 effects in a diabetic patient with Cushing's disease.

  title={Preserved GLP-1 effects in a diabetic patient with Cushing's disease.},
  author={Robert A Ritzel and N. Kleine and Jens Juul Holst and Berend Willms and Wolff H. Schmiegel and Michael A Nauck},
  journal={Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association},
  volume={115 2},
CONTEXT A patient with diabetes mellitus, who participated in a study with intravenous administration of GLP-1, was later found to have Cushing's disease (markedly elevated 24 h urinary cortisol excretion and inadequate suppression of fasting cortisol with 2 mg dexamethasone). His diabetic state disappeared (2 h plasma glucose after 75 g oral glucose 159 mg/dl=IGT) after successful pituitary surgery (normal 24 h urinary cortisol excretion and adequate cortisol suppression with 2 mg… CONTINUE READING


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