Preservation of the Immunogenicity of Dry-powder Influenza H5N1 Whole Inactivated Virus Vaccine at Elevated Storage Temperatures

@inproceedings{Geeraedts2010PreservationOT,
  title={Preservation of the Immunogenicity of Dry-powder Influenza H5N1 Whole Inactivated Virus Vaccine at Elevated Storage Temperatures},
  author={Felix Geeraedts and Vinay Saluja and Wouter ter Veer and Jean-Pierre Amorij and Henderik W Frijlink and Jan Christiaan Wilschut and Wouter L J Hinrichs and Anke L W Huckriede},
  booktitle={The AAPS Journal},
  year={2010}
}
  • Felix Geeraedts, Vinay Saluja, +5 authors Anke L W Huckriede
  • Published in The AAPS Journal 2010
  • Medicine, Chemistry
  • Stockpiling of pre-pandemic influenza vaccines guarantees immediate vaccine availability to counteract an emerging pandemic. Generally, influenza vaccines need to be stored and handled refrigerated to prevent thermal degradation of the antigenic component. Requirement of a cold-chain, however, complicates stockpiling and the logistics of vaccine distribution. We, therefore, investigated the effect of elevated storage temperatures on the immunogenicity of a pre-pandemic influenza A H5N1 whole… CONTINUE READING

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