Preservation of striatal cannabinoid CB1 receptor function correlates with the antianxiety effects of fatty acid amide hydrolase inhibition.

@article{Rossi2010PreservationOS,
  title={Preservation of striatal cannabinoid CB1 receptor function correlates with the antianxiety effects of fatty acid amide hydrolase inhibition.},
  author={Silvia Del Rossi and Valentina De Chiara and Alessandra Musella and Lucia Sacchetti and Cristina Cantarella and Maura Castelli and Francesca Cavasinni and Caterina Motta and Valeria Studer and Giorgio Bernardi and Benjamin F Cravatt and Mauro Maccarrone and Alessandro Usiello and Diego Centonze},
  journal={Molecular pharmacology},
  year={2010},
  volume={78 2},
  pages={260-8}
}
The endocannabinoid anandamide (AEA) plays a crucial role in emotional control, and inhibition of its degradation by the fatty acid amide hydrolase (FAAH) has a potent antianxiety effect. The mechanism by which the magnification of AEA activity reduces anxiety is still largely undetermined. By using FAAH mutant mice and both intraperitoneal and intracerebroventricular administration of the FAAH inhibitor (3'-(aminocarbonyl)[1,1'-biphenyl]-3-yl)-cyclohexylcarbamate (URB597), we found that… CONTINUE READING
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