Preservation of retinal morphology and functions in royal college surgeons rat by nilvadipine, a Ca(2+) antagonist.

@article{Yamazaki2002PreservationOR,
  title={Preservation of retinal morphology and functions in royal college surgeons rat by nilvadipine, a Ca(2+) antagonist.},
  author={Hitoshi Yamazaki and Hiroshi Ohguro and Tadao Maeda and Ikuyo Maruyama and Yoshiko Takano and Tomomi Metoki and Mitsuru Nakazawa and Hajime Sawada and Mari Dezawa},
  journal={Investigative ophthalmology & visual science},
  year={2002},
  volume={43 4},
  pages={919-26}
}
PURPOSE The Royal College of Surgeons (RCS) rat is the most extensively studied animal model for understanding the molecular pathology in inherited retinal degeneration, such as retinitis pigmentosa (RP). The purpose of the present study was to evaluate the pharmacologic effects of several Ca(2+) antagonists on the retinal degeneration of RCS rats. METHODS Several Ca(2+) antagonists, diltiazem, nicardipine, nilvadipine, and nifedipine, were intraperitoneally administered and retinal… CONTINUE READING