Preservation of neuroendocrine control of reproductive function despite severe undernutrition.

  title={Preservation of neuroendocrine control of reproductive function despite severe undernutrition.},
  author={Karen Klahr Miller and Steven Grinspoon and Suzanne Gleysteen and Kelly A. Grieco and Julia Ciampa and Jeffrey Breu and David B. Herzog and Anne Klibanski},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={89 9},
Anorexia nervosa (AN) is characterized by low weight and self-imposed caloric restriction and leads to severe bone loss. Although amenorrhea due to acquired GnRH deficiency is nearly universal in AN, a subset of patients maintains menses despite low weight. The mechanisms underlying continued GnRH secretion despite low weight in these patients and the impact of gonadal hormone secretion on bone mineral density (BMD) in such eumenorrheic, low-weight patients remain unknown. We hypothesized that… CONTINUE READING
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