Preservation of intrahepatic hepatitis C virus (HCV)-specific CD4+ T cell responses despite global loss of CD4+ T cells in HCV/HIV coinfection.

@article{Morishima2007PreservationOI,
  title={Preservation of intrahepatic hepatitis C virus (HCV)-specific CD4+ T cell responses despite global loss of CD4+ T cells in HCV/HIV coinfection.},
  author={Chihiro Morishima and Margaret C Shuhart and Christina S Yoshihara and Denise M. Paschal and Melissa Andreia de Moraes Silva and Lisa V Thomassen and Scott S. Emerson and David R. Gretch},
  journal={The Journal of infectious diseases},
  year={2007},
  volume={196 4},
  pages={
          577-86
        }
}
BACKGROUND Human immunodeficiency virus (HIV) coinfection and low peripheral blood CD4(+) T cell counts are associated with increased hepatitis C liver disease. METHODS Hepatitis C virus (HCV)-specific CD4(+) T cell responses were assessed using interferon (IFN)- gamma enzyme-linked immunospot assays on peripheral blood mononuclear cells and expanded liver lymphocytes from HCV-monoinfected and HCV/HIV-coinfected subjects. Cell frequencies were determined using flow cytometry. RESULTS HIV… CONTINUE READING