Preservation of in vitro function of platelets stored in the presence of a synthetic dual inhibitor of factor Xa and thrombin.

@article{Hellstern2007PreservationOI,
  title={Preservation of in vitro function of platelets stored in the presence of a synthetic dual inhibitor of factor Xa and thrombin.},
  author={Peter Hellstern and Uta St{\"u}rzebecher and B Wuchold and Hanne Haubelt and Ulrich Theo Seyfert and Michael Bauer and Anette Vogt and J{\"o}rg St{\"u}rzebecher},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2007},
  volume={5 10},
  pages={2119-26}
}
BACKGROUND The use of citrate anticoagulant limits the clinical significance of platelet function tests. Thrombin inhibitors cannot prevent thrombin-induced platelet activation completely. We examined the influence of benzylsulfonyl-d-Arg-Pro-4-amidinobenzylamide (BAPA), a dual inhibitor of Factor Xa (FXa) and thrombin, on platelet responsiveness to agonists when measured between 2 and 24 h after venipuncture. METHODS Blood samples from 36 individuals were anticoagulated with citrate and BAPA… CONTINUE READING

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Turbidimetric platelet aggregometry ( TPA ) and impedance platelet aggregometry ( IPA ) , a whole blood platelet counting assay for measuring platelet aggregation ( PCA ) , and Platelet Function Anlayzer-100 ( PFA-100 closure times ( CTs ) were determined after whole blood storage between 2 and 24 h after venipuncture .
Turbidimetric platelet aggregometry ( TPA ) and impedance platelet aggregometry ( IPA ) , a whole blood platelet counting assay for measuring platelet aggregation ( PCA ) , and Platelet Function Anlayzer-100 ( PFA-100 closure times ( CTs ) were determined after whole blood storage between 2 and 24 h after venipuncture .
Turbidimetric platelet aggregometry ( TPA ) and impedance platelet aggregometry ( IPA ) , a whole blood platelet counting assay for measuring platelet aggregation ( PCA ) , and Platelet Function Anlayzer-100 ( PFA-100 closure times ( CTs ) were determined after whole blood storage between 2 and 24 h after venipuncture .
Turbidimetric platelet aggregometry ( TPA ) and impedance platelet aggregometry ( IPA ) , a whole blood platelet counting assay for measuring platelet aggregation ( PCA ) , and Platelet Function Anlayzer-100 ( PFA-100 closure times ( CTs ) were determined after whole blood storage between 2 and 24 h after venipuncture .
Turbidimetric platelet aggregometry ( TPA ) and impedance platelet aggregometry ( IPA ) , a whole blood platelet counting assay for measuring platelet aggregation ( PCA ) , and Platelet Function Anlayzer-100 ( PFA-100 closure times ( CTs ) were determined after whole blood storage between 2 and 24 h after venipuncture .
Turbidimetric platelet aggregometry ( TPA ) and impedance platelet aggregometry ( IPA ) , a whole blood platelet counting assay for measuring platelet aggregation ( PCA ) , and Platelet Function Anlayzer-100 ( PFA-100 closure times ( CTs ) were determined after whole blood storage between 2 and 24 h after venipuncture .
Turbidimetric platelet aggregometry ( TPA ) and impedance platelet aggregometry ( IPA ) , a whole blood platelet counting assay for measuring platelet aggregation ( PCA ) , and Platelet Function Anlayzer-100 ( PFA-100 closure times ( CTs ) were determined after whole blood storage between 2 and 24 h after venipuncture .
Turbidimetric platelet aggregometry ( TPA ) and impedance platelet aggregometry ( IPA ) , a whole blood platelet counting assay for measuring platelet aggregation ( PCA ) , and Platelet Function Anlayzer-100 ( PFA-100 closure times ( CTs ) were determined after whole blood storage between 2 and 24 h after venipuncture .
Turbidimetric platelet aggregometry ( TPA ) and impedance platelet aggregometry ( IPA ) , a whole blood platelet counting assay for measuring platelet aggregation ( PCA ) , and Platelet Function Anlayzer-100 ( PFA-100 closure times ( CTs ) were determined after whole blood storage between 2 and 24 h after venipuncture .
Turbidimetric platelet aggregometry ( TPA ) and impedance platelet aggregometry ( IPA ) , a whole blood platelet counting assay for measuring platelet aggregation ( PCA ) , and Platelet Function Anlayzer-100 ( PFA-100 closure times ( CTs ) were determined after whole blood storage between 2 and 24 h after venipuncture .
The use of citrate anticoagulant limits the clinical significance of platelet function tests .
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