Preservation of cone photoreceptors after a rapid yet transient degeneration and remodeling in cone-only Nrl-/- mouse retina.

@article{Roger2012PreservationOC,
  title={Preservation of cone photoreceptors after a rapid yet transient degeneration and remodeling in cone-only Nrl-/- mouse retina.},
  author={Jerome E Roger and Keerthi Ranganath and Lian Zhao and Radu Cojocaru and Matthew Bryan Brooks and Norimoto Gotoh and Shobi Veleri and Avinash Hiriyanna and Rivka A. Rachel and Maria Mercedes Campos and Robert N Fariss and Wai T Wong and Anand Swaroop},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2012},
  volume={32 2},
  pages={528-41}
}
Cone photoreceptors are the primary initiator of visual transduction in the human retina. Dysfunction or death of rod photoreceptors precedes cone loss in many retinal and macular degenerative diseases, suggesting a rod-dependent trophic support for cone survival. Rod differentiation and homeostasis are dependent on the basic motif leucine zipper transcription factor neural retina leucine zipper (NRL). The loss of Nrl (Nrl(-/-)) in mice results in a retina with predominantly S-opsin-containing… CONTINUE READING