Preservation of canine myocardial high-energy phosphates during low-flow ischemia with modification of hemoglobin-oxygen affinity.

@article{Weiss1999PreservationOC,
  title={Preservation of canine myocardial high-energy phosphates during low-flow ischemia with modification of hemoglobin-oxygen affinity.},
  author={Robert G. Weiss and Maricruz Alvarez Mejia and David A. Kass and Anthony Dipaula and Lewis C. Becker and Gary Gerstenblith and Vadappuram P. Chacko},
  journal={The Journal of clinical investigation},
  year={1999},
  volume={103 5},
  pages={739-46}
}
Conventional approaches for the treatment of myocardial ischemia increase coronary blood flow or reduce myocardial demand. To determine whether a rightward shift in the hemoglobin-oxygen saturation curve would reduce the metabolic and contractile effects of a myocardial oxygen-supply imbalance, we studied the impact of a potent synthetic allosteric modifier of hemoglobin-oxygen affinity, a 2-[4-[[(3,5-disubstituted anilino)carbonyl]methyl] phenoxy] -2-methylproprionic acid derivative (RSR13… CONTINUE READING

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Non-linear least squares analysis of in vivo 31P NMR data. Book of abstracts for the Society of Magnetic Resonance in Medicine

  • P. B. Barker, S. Sibisi
  • (Abstr.)
  • 1990

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