Presentation and management of osteoporosis presenting in association with pregnancy or lactation

@article{Kovacs2015PresentationAM,
  title={Presentation and management of osteoporosis presenting in association with pregnancy or lactation},
  author={Christopher S. Kovacs and S H Ralston},
  journal={Osteoporosis International},
  year={2015},
  volume={26},
  pages={2223-2241}
}
In this review, we summarize our current understanding of the pathophysiology of fragility fractures that occur for the first time during pregnancy and lactation, and provide guidance on appropriate investigations and treatment strategies. Most affected women will have had no prior bone density reading, and so the extent of bone loss that may have occurred during pregnancy or lactation is uncertain. During pregnancy, intestinal calcium absorption doubles in order to meet the fetal demand for… 
Intertrochanteric fracture in pregnancy- and lactation-associated osteoporosis
TLDR
A 33-year-old patient who presented with a left intertrochanteric fracture after falling from standing height at 10 months postpartum was diagnosed with pregnancy- and lactation-associated osteoporosis because of a considerable decrease in bone mineral density.
"Pregnancy and Lactation Associated Osteoporosis".
TLDR
Pregnancy-associated osteoporosis is a rare condition of skeletal fragility affecting women in pregnancy or the postpartum period and management of PAO is challenging, due both to a poor evidence base and the fact that spontaneous improvement in BMD is known to occur once pregnancy and lactation are complete.
A case of pregnancy and lactation-associated osteoporosis and a review of the literature
TLDR
Increased bone resorption significantly increases the risk of bone fractures in women with PLO, and early diagnosis, stopping breastfeeding, treatment of calcium and vitamin D, bisphosphonates, or other antiosteoporosis medicine and regular follow-ups are particularly important in the prevention of fractures and to increase the quality of life of patients.
Clinical Case: Pregnancy lactation osteoporosis
Pregnancy-lactation osteoporosis (PLO) is a rare condition with most cases appearing during the third trimester of pregnancy or early in the post-partum period, especially in primigravid women. Our
Analysis of Fracture Incidence in 135 Patients With Pregnancy and Lactation Osteoporosis (PLO)
TLDR
The research database TriNetX was used to perform a query selecting women between the ages of 10 and 50 years old who experienced an osteoporotic fracture within 12 months of pregnancy to determine the incidence of fractures and evaluated the medications that were utilized in the patients who received treatment.
[Pregnancy and lactation-associated osteoporosis].
TLDR
The clinical course of a 37-year-old patient with PLO, who suffered 6 vertebral fractures, is reported, which significantly improved and teriparatid and bisphosphonates seem to be the best option.
Pregnancy and lactation, a challenge for the skeleton
TLDR
Pregnancy- and lactation-induced osteoporosis (PLO) is a rare disease for which the pathophysiological mechanism is as yet incompletely known; here, the possible roles of genetics, oxytocin, sympathetic tone and bone marrow fat are speculated on.
A case of pregnancy and lactation associated osteoporosis in the third pregnancy; robust response to teriparatide despite delayed administration
TLDR
PLO should be considered in patients who complain with back pain during late pregnancy and postpartum period and teriparatide may be an effective option to improve the recovery of BMD if there is not enough improvement with conventional treatment.
Control of Mineral and Skeletal Homeostasis During Pregnancy and Lactation
TLDR
Pregnancy and lactation invoke a substantial demand on the mother to supply calcium and other minerals to her offspring, and this is met by different adaptations within each time period, but for most women these acute changes in mineral metabolism do not affect long-term fragility or maintenance of bone mass.
Pregnancy and Lactation-Associated Osteoporosis: Bone Histomorphometric Analysis and Response to Treatment with Zoledronic Acid
TLDR
Bone histomorphometry showed a high resorption rate and excellent evolution after 1 year of treatment with intravenous zoledronic acid, suggesting that osteoclastogenesis plays a central role in the pathophysiological processes of this disease.
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