Present state and future perspectives of using pluripotent stem cells in toxicology research

@inproceedings{Wobus2010PresentSA,
  title={Present state and future perspectives of using pluripotent stem cells in toxicology research},
  author={Anna M. Wobus and Peter L{\"o}ser},
  booktitle={Archives of Toxicology},
  year={2010}
}
The use of novel drugs and chemicals requires reliable data on their potential toxic effects on humans. Current test systems are mainly based on animals or in vitro–cultured animal-derived cells and do not or not sufficiently mirror the situation in humans. Therefore, in vitro models based on human pluripotent stem cells (hPSCs) have become an attractive alternative. The article summarizes the characteristics of pluripotent stem cells, including embryonic carcinoma and embryonic germ cells, and… CONTINUE READING