Present and future of 5-HT receptor agonists as antimigraine drugs.

@article{Pauwels1999PresentAF,
  title={Present and future of 5-HT receptor agonists as antimigraine drugs.},
  author={Petrus Johan Pauwels and Gareth W. John},
  journal={Clinical neuropharmacology},
  year={1999},
  volume={22 3},
  pages={123-36}
}
Serotonin (5-hydroxytryptamine; 5-HT) is thought to play an important role in the pathogenesis of migraine. The discovery of the 5-HT1B/1D/1F agonist sumatriptan constitutes a substantial advance in the acute treatment of migraine, though it displays a number of nonnegligible shortcomings. Today, a number of second-generation drugs derived from tryptamine are under advanced clinical development or are about to be marketed worldwide for the acute treatment of migraine. These tryptamine… CONTINUE READING

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