Presensitization: the problem and its management.

  title={Presensitization: the problem and its management.},
  author={Stanley C. Jordan and Mark D. Pescovitz},
  journal={Clinical journal of the American Society of Nephrology : CJASN},
  volume={1 3},
Much attention has been placed recently on transplantation in highly HLA-sensitized patients. In attempts to remove these antibodies and enable successful transplantation, several novel approaches have been developed. These include intravenous Ig (IVIg), mycophenolate mofetil, sirolimus, alemtuzumab, protein A immunoabsorption, and rituximab. IVIg has emerged as a very effective agent when used alone in high dose or when used in low dose and combined with plasmapheresis. Although alemtuzumab… CONTINUE READING


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