Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

Abstract

Following ectodomain shedding, Notch-1 undergoes presenilin (PS)-dependent constitutive intramembranous endoproteolysis at site-3. This cleavage is similar to the PS-dependent gamma-secretase cleavage of the beta-amyloid precursor protein (betaAPP). However, topological differences in cleavage resulting in amyloid beta-peptide (Abeta) or the Notch-1… (More)

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Cite this paper

@article{Okochi2002PresenilinsMA, title={Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.}, author={Masayasu Okochi and Harald Steiner and Akio Fukumori and Hisashi Tanii and Taisuke Tomita and Toshihisa Tanaka and Takeshi Iwatsubo and Takashi Kudo and Masatoshi Takeda and Christian Haass}, journal={The EMBO journal}, year={2002}, volume={21 20}, pages={5408-16} }