Presenilins are required for maintenance of neural stem cells in the developing brain

@article{Kim2007PresenilinsAR,
  title={Presenilins are required for maintenance of neural stem cells in the developing brain},
  author={Woo-Young Kim and Jie Shen},
  journal={Molecular Neurodegeneration},
  year={2007},
  volume={3},
  pages={2 - 2}
}
The early embryonic lethality of mutant mice bearing germ-line deletions of both presenilin genes precluded the study of their functions in neural development. We therefore employed the Cre-loxP technology to generate presenilin conditional double knockout (PS cDKO) mice, in which expression of both presenilins is inactivated in neural progenitor cells (NPC) or neural stem cells and their derivative neurons and glia beginning at embryonic day 11 (E11). In PS cDKO mice, dividing NPCs labeled by… CONTINUE READING