Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1.

@article{Zhang2000PresenilinsAR,
  title={Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1.},
  author={Zaixiang Zhang and Philip M. Nadeau and W Song and Dorit B. Donoviel and Ming Yuan and Alan Bernstein and Bruce A. Yankner},
  journal={Nature cell biology},
  year={2000},
  volume={2 7},
  pages={463-5}
}

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