Presenilins and Alzheimer disease: the calcium conspiracy

  title={Presenilins and Alzheimer disease: the calcium conspiracy},
  author={Gopal Thinakaran and Sangram S. Sisodia},
  journal={Nature Neuroscience},
Alzheimer disease (AD) affects over 4 million people in the United States alone. Most cases of AD are sporadic, but about 10% of all AD cases are inherited. These forms of familial AD (FAD) are usually earlyonset (that is, the individual develops the disease before 65 years of age or so) and inherited as an autosomal dominant trait. The discovery that mutations in the PSEN1 and PSEN2 genes cause FAD spawned a wealth of molecular and cellular investigations aimed at unraveling the mechanisms by… CONTINUE READING


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Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk.

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N at ur e P ub lis hi ng G ro up ht tp

I. F. Smith, K. N. Green, F. M. LaFerla
Cell Calcium • 2005

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