Presenilins: how much more than γ-secretase?!

Abstract

AD (Alzheimer's disease) is a neurodegenerative disease characterized by a gradual loss of neurons and the accumulation of neurotoxic Aβ (amyloid β-peptide) and hyperphosphorylated tau. The discovery of mutations in three genes, PSEN1 (presenilin 1), PSEN2 (presenilin 2) and APP (amyloid precursor protein), in patients with FAD (familial AD) has made an… (More)
DOI: 10.1042/BST0381474

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Cite this paper

@article{Coen2010PresenilinsHM, title={Presenilins: how much more than γ-secretase?!}, author={Katrijn Coen and Wim G. Annaert}, journal={Biochemical Society transactions}, year={2010}, volume={38 6}, pages={1474-8} }