Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels.

@article{Zatti2006PresenilinML,
  title={Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels.},
  author={Giancarlo Zatti and Andrea Burgo and Marta Giacomello and Laura Barbiero and Roberta Ghidoni and Giulietta Sinigaglia and Cristina Florean and Silvia Bagnoli and Giuliano Binetti and Sandro Sorbi and Paola Pizzo and Cristina Fasolato},
  journal={Cell calcium},
  year={2006},
  volume={39 6},
  pages={539-50}
}
Presenilin-1 and -2 (PS1 and PS2) mutations, the major cause of familial Alzheimer's disease (FAD), have been causally implicated in the pathogenesis of neuronal cell death through a perturbation of cellular Ca(2+) homeostasis. We have recently shown that, at variance with previous suggestions obtained in cells expressing other FAD-linked PS mutations, PS2-M239I and PS2-T122R cause a reduction and not an increase in cytosolic Ca(2+) rises induced by Ca(2+) release from stores. In this… CONTINUE READING

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