Presenilin function in Caenorhabditis elegans.

  title={Presenilin function in Caenorhabditis elegans.},
  author={Agata Smialowska and Ralf Baumeister},
  journal={Neuro-degenerative diseases},
  volume={3 4-5},
The genome of the nematode Caenorhabditis elegans contains homologs of several genes associated with familial Alzheimer's disease in humans. apl-1 encodes a transmembrane protein belonging to the amyloid precursor protein family, sel-12 and hop-1 are the two somatically expressed presenilin genes that resemble PS1 and PS2 on both a structural and a… CONTINUE READING