Presenilin-dependent regulated intramembrane proteolysis and γ-secretase activity

  title={Presenilin-dependent regulated intramembrane proteolysis and γ-secretase activity},
  author={Justin McCarthy and Ciara Twomey and Peter Wujek},
  journal={Cellular and Molecular Life Sciences},
Inhibiting the production of amyloid-β by antagonising γ-secretase activity is currently being pursued as a therapeutic strategy for Alzheimer’s disease (AD). However, early pre-clinical studies have demonstrated that disruption of presenilin-dependent γ-secretase alters many presenilin-dependent processes, leading to early lethality in several AD model organisms. Subsequently, transgenic animal studies have highlighted several gross developmental side effects arising from presenilin deficiency… CONTINUE READING

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