Presenilin-dependent "gamma-secretase" processing of deleted in colorectal cancer (DCC).

  title={Presenilin-dependent "gamma-secretase" processing of deleted in colorectal cancer (DCC).},
  author={Yoshihito Taniguchi and Seong-hun Kim and Sangram S. Sisodia},
  journal={The Journal of biological chemistry},
  volume={278 33},
The presenilin-gamma-secretase complex plays a critical role in mediating intramembranous proteolysis of several type I membrane proteins, including beta-amyloid precursor protein (APP) and Notch. We now show that deleted in colorectal cancer (DCC) is subject to proteolysis within the ectodomain segment both in cultured cells and in vivo and that the residual membrane-tethered DCC "stub" is subsequently processed by gamma-secretase to generate a derivative termed DCC-intracellular domain (ICD… CONTINUE READING


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