Presenilin-Mediated Modulation of Capacitative Calcium Entry

  title={Presenilin-Mediated Modulation of Capacitative Calcium Entry},
  author={Andrew S. Yoo and Isaac Cheng and Sungkwon Chung and Tallessyn Z Grenfell and Hanmi Lee and Eunju Pack-Chung and Melissa Handler and Jie Shen and Weiming Xia and Giuseppina Tesco and Aleister J Saunders and Kai Ding and Matthew P. Frosch and Rudolph E. Tanzi and Tae-wan Kim},
We studied a novel function of the presenilins (PS1 and PS2) in governing capacitative calcium entry (CCE), a refilling mechanism for depleted intracellular calcium stores. Abrogation of functional PS1, by either knocking out PS1 or expressing inactive PS1, markedly potentiated CCE, suggesting a role for PS1 in the modulation of CCE. In contrast, familial Alzheimer's disease (FAD)-linked mutant PS1 or PS2 significantly attenuated CCE and store depletion-activated currents. While inhibition of… CONTINUE READING


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Store - oper - USA 94 , 2025 – 2030 . ated Ca 2 1 entry : evidence for a secretion - like coupling model

  • R. L. Patterson, D. B. van Rossum, D. L. Gill
  • Cell
  • 1999
Highly Influential
4 Excerpts

to familial Alzheimer’s disease

  • Y. Yao, A. V. Ferrer-Montiel, M. Montal, R. Y. Tsien
  • Nat. Med. 2, 864–870.
  • 1999
Highly Influential
1 Excerpt

Enhanced production and oligonerization

  • D. Scheuner, C. Eckman, M. Jensen, X. M. Song, M. Citron, Su
  • ing mutant presenilins. J. Biol. Chem
  • 1996
Highly Influential
3 Excerpts

Notch and presenilins in vertebrates and inverte- Res

  • Curr. Opin. Neurobiol
  • 2000

Presenilin The presenilin 2 mutations (N141I) linked to familial

  • A. M. well, I. Cheng, R. E. Tanzi, Kim, T.-W
  • 2000

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