Presenilin Function in Caenorhabditis elegans

@article{Smialowska2006PresenilinFI,
  title={Presenilin Function in Caenorhabditis elegans},
  author={Agata Smialowska and Ralf Baumeister},
  journal={Neurodegenerative Diseases},
  year={2006},
  volume={3},
  pages={227 - 232}
}
The genome of the nematode Caenorhabditis elegans contains homologs of several genes associated with familial Alzheimer’s disease in humans. apl-1 encodes a transmembrane protein belonging to the amyloid precursor protein family, sel-12 and hop-1 are the two somatically expressed presenilin genes that resemble PS1 and PS2 on both a structural and a functional level. Mutations in the sel-12-encoded presenilin gene cause defective Notch/lin-12 signaling and result in reduced egg-laying, caused by… 

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