Presenilin 1-related alterations in DNA integrity in a transgenic mouse model of Alzheimer's disease.

@article{Michelsen2010Presenilin1A,
  title={Presenilin 1-related alterations in DNA integrity in a transgenic mouse model of Alzheimer's disease.},
  author={Kimmo A. Michelsen and Hubert Korr and Harry W. M. Steinbusch and Christoph Schmitz},
  journal={Brain research},
  year={2010},
  volume={1316},
  pages={139-44}
}
The present study tested the hypothesis that mutations in amyloid precursor protein (APP) and presenilin (PS) 1 result in alterations in the amount of nuclear (n) DNA repair and nDNA damage in neurons in vivo. To this end, the relative amount of nDNA repair was measured in 8-month-old transgenic mice expressing either human mutant APP (APP751(SL) mice), human mutant PS1 (PS1(M146L) mice) or both human mutant APP and PS1 (APP751(SL)/PS1(M146L) mice) with unscheduled DNA synthesis, and the… CONTINUE READING

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